QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies

@article{Whiting2011QUADAS2AR,
  title={QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies},
  author={Penny F. Whiting and Anne W.S. Rutjes and Marie E. Westwood and Susan Mallett and Jonathan J. Deeks and Johannes B. Reitsma and Mariska M. G. Leeflang and Jonathan A. C. Sterne and Patrick M. M. Bossuyt},
  journal={Annals of Internal Medicine},
  year={2011},
  volume={155},
  pages={529 - 536}
}
In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk… 
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References

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The aim of this project was to combine empirical evidence and expert opinion in a formal consensus method to develop a tool to be used in systematic reviews to assess the quality of primary studies of diagnostic accuracy.
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TLDR
The evaluation highlighted particular difficulties in scoring the items on uninterpretable results and withdrawals, and it is essential that reviewers tailor guidelines for scoring items to their review, and ensure that all reviewers are clear on how to score studies.
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TLDR
Different methods of weighting items included in a quality assessment tool for diagnostic accuracy studies (QUADAS) to produce an overall quality score were used, and the effects of incorporating these into a systematic review were examined.
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