QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia

@article{Ozeki2010QTcPA,
  title={QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia},
  author={Y. Ozeki and K. Fujii and N. Kurimoto and N. Yamada and M. Okawa and T. Aoki and J. Takahashi and N. Ishida and M. Horie and H. Kunugi},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2010},
  volume={34},
  pages={401-405}
}
  • Y. Ozeki, K. Fujii, +7 authors H. Kunugi
  • Published 2010
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Many antipsychotic drugs cause QT prolongation, although the effect differs based on the particular drug. We sought to determine the potential for antipsychotic drugs to prolong the QTc interval (>470 ms in men and >480 ms in women) using the Bazett formula in a "real-world" setting by analyzing the electrocardiograms of 1017 patients suffering from schizophrenia. Using logistic regression analysis to calculate the adjusted relative risk (RR), we found that chlorpromazine (RR for 100 mg=1.37… Expand
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