QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep

@article{Poissant2012QTLMF,
  title={QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep},
  author={Jocelyn Poissant and Corey S. Davis and Ren{\'e} M Malenfant and John T Hogg and David W. Coltman},
  journal={Heredity},
  year={2012},
  volume={108},
  pages={256-263}
}
Dissecting the genetic architecture of fitness-related traits in wild populations is key to understanding evolution and the mechanisms maintaining adaptive genetic variation. We took advantage of a recently developed genetic linkage map and phenotypic information from wild pedigreed individuals from Ram Mountain, Alberta, Canada, to study the genetic architecture of ecologically important traits (horn volume, length, base circumference and body mass) in bighorn sheep. In addition to estimating… 
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References

SHOWING 1-10 OF 68 REFERENCES
MAPPING QUANTITATIVE TRAIT LOCI UNDERLYING FITNESS-RELATED TRAITS IN A FREE-LIVING SHEEP POPULATION
TLDR
The prospects for refining estimates of QTL position and effect size in the study population, and for QTL searches in free-living pedigrees in general, are discussed.
A genome scan for quantitative trait loci in a wild population of red deer (Cervus elaphus).
TLDR
An attempt to map quantitative trait loci for birth weight in an unmanipulated, wild population of red deer (Cervus elaphus) is described, the first time that a QTL for any trait has been mapped in a wild mammal population.
Genetic linkage map of a wild genome: genomic structure, recombination and sexual dimorphism in bighorn sheep
TLDR
A first-generation bighorn sheep linkage map is developed that will facilitate future studies of the genetic architecture of trait variation in this species and suggests that domestication may have played a role in altering patterns of heterochiasmy.
Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight
TLDR
A custom maximum likelihood program was developed to map QTL in half-sib families for non-inbred strains (QTL-MLE) and is freely available on request and offers the advantage of enabling QTL × fixed effect interactions to be included in the model.
Quantitative genetics and sex-specific selection on sexually dimorphic traits in bighorn sheep
TLDR
The absence of detectable sexually antagonistic selection suggests that currently there are no sexual conflicts at loci influencing horn volume and body mass in a wild population of bighorn sheep.
Mapping of quantitative trait loci for growth and carcass traits in commercial sheep populations.
TLDR
Based on the phenotypic effect and location of the QTL, the data suggest that a locus similar to the Carwell locus may be segregating in the United Kingdom Texel population.
A strong quantitative trait locus for wing length on chromosome 2 in a wild population of great reed warblers
TLDR
The results provide a first important step into understanding the genetic architecture of avian wing length, and give opportunities to study the evolutionary dynamics of wing length at the locus level.
Combining population genomics and quantitative genetics: finding the genes underlying ecologically important traits
TLDR
It is argued that a combination of the two approaches, population genomics and quantitative genetic approaches, provides a powerful approach to uncovering the molecular mechanisms responsible for adaptation.
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
TLDR
A set of analytical methods that modify and extend the classical theory for mapping quantitative trait loci (QTLs) and allow a substantial reduction in the number of progeny that need to be scored with the DNA markers.
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