QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol.

@article{Somberg2010QTPA,
  title={QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol.},
  author={John Charin Somberg and Richard A. Preston and Vasant V Ranade and Janos Molnar},
  journal={Cardiology},
  year={2010},
  volume={116 3},
  pages={219-25}
}
OBJECTIVES The aim of this study was to evaluate the correlation between QT interval (QT) and serum sotalol concentration following a single low dose of oral and intravenous sotalol. METHODS Fifteen healthy volunteers received 75 mg intravenous sotalol over 2.5 h and 80 mg oral sotalol in a random order. Serum sotalol concentrations and 12-lead electrocardiograms were obtained simultaneously at baseline and 7 times following dosings. Rate-corrected QT (QTc) was calculated by the Bazett… CONTINUE READING

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