QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.

@article{Cubeddu2003QTPA,
  title={QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs.},
  author={Luigi X. Cubeddu},
  journal={American journal of therapeutics},
  year={2003},
  volume={10 6},
  pages={452-7}
}
A long QT interval due to prolonged repolarization may be associated with a polymorphic ventricular tachycardia known as torsades de pointes. During marked prolongation of the action potential (long QT) early after depolarizations may occur, which when propagated may trigger an arrhythmia. The duration of QTc interval is the major determinant of the risk of drug-induced torsades. Congenital long QT syndrome, female gender, hypokalemia and use of sympathomimetics increase the risk of torsades… CONTINUE READING