QT interval prolongation and cardiac risk assessment for novel drugs.


Fatal cardiac arrhythmias, known as torsades de pointes, can occur with a wide variety of medicinal drugs and are associated with prolongation of the QT interval. This review critically evaluates the major strategies for assessing QT prolongation risk: ion channel studies, in vitro cardiac electrophysiology, and in vivo cardiac electrophysiology and… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.