QT interval in children and infants receiving cisapride.

  title={QT interval in children and infants receiving cisapride.},
  author={Arie Levine and Rami Fogelman and Leah Sirota and Zili Zangen and Raanan Shamir and Gabriel Dinari},
  volume={101 3},
OBJECTIVES Life-threatening arrhythmias and prolonged QT interval have been reported in adults and children using cisapride, a medication structurally similar to procainamide. Premature infants have reduced activity of cytochrome p-450, the system responsible for metabolism of cisapride, which could lead to QT prolongation. Therefore, we prospectively studied premature infants and children receiving cisapride to analyze the effect of prolonged cisapride therapy on QT interval. DESIGN… CONTINUE READING