QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial.

@article{Wedam2007QTintervalEO,
  title={QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial.},
  author={Erich F. Wedam and George E. Bigelow and Rolley E. Johnson and Paul A. Nuzzo and Mark C P Haigney},
  journal={Archives of internal medicine},
  year={2007},
  volume={167 22},
  pages={
          2469-75
        }
}
BACKGROUND Levomethadyl acetate, methadone hydrochloride, and buprenorphine hydrochloride are equally effective treatments for opioid dependence. Each blocks the human ether-a-go-go-related gene (hERG)-associated channel in vitro and represents a risk for QT prolongation. To compare the effects of 3 known hERG-associated channel blockers on the corrected QT (QTc), we conducted a randomized, controlled trial of opioid-addicted subjects. METHODS We analyzed 12-lead electrocardiograms collected… 

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