QSAR studies on 1-phenylbenzimidazoles as inhibitors of the platelet-derived growth factor.

@article{Katritzky2005QSARSO,
  title={QSAR studies on 1-phenylbenzimidazoles as inhibitors of the platelet-derived growth factor.},
  author={Alan R. Katritzky and Dimitar A. Dobchev and Dan C. Fara and Mati Karelson},
  journal={Bioorganic & medicinal chemistry},
  year={2005},
  volume={13 24},
  pages={
          6598-608
        }
}
This work is devoted to the development of quantitative structure-activity relationship (QSAR) models of the biological activity of 123 1-phenylbenzimidazoles as inhibitors of the PDGF receptor. The molecular features are represented by chemical descriptors that have been calculated on geometrical, topological, quantum mechanical, and electronic basis by using CODESSA PRO. The obtained models, linear (multilinear regression) and nonlinear (artificial neural network), are aimed to link the… CONTINUE READING
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