QSAR modeling of a set of pyrazinoate esters as antituberculosis prodrugs.

Abstract

Tuberculosis is an infection caused mainly by Mycobacterium tuberculosis. A first-line antimycobacterial drug is pyrazinamide (PZA), which acts partially as a prodrug activated by a pyrazinamidase releasing the active agent, pyrazinoic acid (POA). As pyrazinoic acid presents some difficulty to cross the mycobacterial cell wall, and also the pyrazinamide… (More)
DOI: 10.1002/ardp.200900216

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Cite this paper

@article{Fernandes2010QSARMO, title={QSAR modeling of a set of pyrazinoate esters as antituberculosis prodrugs.}, author={Jo{\~a}o Paulo Dos Santos Fernandes and Kerly F. M. Pasqualoto and Veni Maria Andres Felli and Elizabeth I. Ferreira and Carlos A. Brandt}, journal={Archiv der Pharmazie}, year={2010}, volume={343 2}, pages={91-7} }