QSAR analysis for ADA upon interaction with a series of adenine derivatives as inhibitors.

@article{MoosaviMovahedi2004QSARAF,
  title={QSAR analysis for ADA upon interaction with a series of adenine derivatives as inhibitors.},
  author={Ali Akbar Moosavi-Movahedi and Shahrokh Safarian and Gholam Hosain Hakimelahi and Gholamreza Ataei and Davood Ajloo and S Panjehpour and Siavash Riahi and Mir Fazlollah Mousavi and Sona S. Mardanyan and Naser Soltani and Ali Khalafi-Nezhad and Hashem Sharghi and H Moghadamnia and Ali Akbar Saboury},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2004},
  volume={23 3},
  pages={613-24}
}
The kinetic parameters of adenosine deaminase such as Km and Ki were determined in the absence and presence of adenine derivatives (R1-R24) in sodium phosphate buffer (50 mM; pH 7.5) solution at 27 degrees C. These kinetic parameters were used for QSAR analysis. As such, we found some theoretical descriptors to which the binding affinity of adenosine… CONTINUE READING