• Corpus ID: 97588740

QSAR Rationales for the 5-HT2A Receptor Antagonistic Activity of 2-Alkyl-4- aryl-Pyrimidine Fused Heterocycles.

@inproceedings{Choudhary2015QSARRF,
  title={QSAR Rationales for the 5-HT2A Receptor Antagonistic Activity of 2-Alkyl-4- aryl-Pyrimidine Fused Heterocycles.},
  author={Manjusha Choudhary and Pradeep Pilania and Brij Kishore Sharma},
  year={2015}
}
The 5-HT2A receptor binding affinities of the 2-alkyl-4-aryl-pyrimidine fused heterocycles have been quantitatively expressed in terms of topological and molecular features. The analysis revealed that less number of rotatable bonds (descriptor RBN), a more hydrophobic nature (descriptor MLOGP) and less polar surface area (descriptor PSA) in a molecular structure will be favorable to the binding affinity. A lower positive values of descriptors PW4 (path/walk 4 Randic shape index) and MATS2m… 
In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson’s Disease
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The modulation of specific GPCRs potentially implicated in PD, excluding dopamine receptors, may provide promising non-dopaminergic therapeutic alternatives for symptomatic treatment of PD.

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Information Theory and an Extension of the Maximum Likelihood Principle
TLDR
The classical maximum likelihood principle can be considered to be a method of asymptotic realization of an optimum estimate with respect to a very general information theoretic criterion to provide answers to many practical problems of statistical model fitting.