QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni

@article{MeloFilho2016QSARDrivenDO,
  title={QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni},
  author={Cleber C. Melo-Filho and Rafael F. Dantas and Rodolpho C. Braga and Bruno J. Neves and Mario R. Senger and Walter C. G. Valente and Jo{\~a}o M. Rezende-Neto and Willian T. Chaves and Eugene N. Muratov and Ross A. Paveley and Nicholas Furnham and Lee Kamentsky and Anne E. Carpenter and Floriano Silva-Junior and Carolina Horta Andrade},
  journal={Journal of chemical information and modeling},
  year={2016},
  volume={56 7},
  pages={1357-72}
}
Schistosomiasis is a neglected tropical disease that affects millions of people worldwide. Thioredoxin glutathione reductase of Schistosoma mansoni (SmTGR) is a validated drug target that plays a crucial role in the redox homeostasis of the parasite. We report the discovery of new chemical scaffolds against S. mansoni using a combi-QSAR approach followed by… CONTINUE READING