QSAR: hydropathic analysis of inhibitors of the p53-mdm2 interaction.

  title={QSAR: hydropathic analysis of inhibitors of the p53-mdm2 interaction.},
  author={Peter S. Galatin and Donald J. Abraham},
  volume={45 3},
To date, a number of p53-derived peptides have been evaluated in vitro for their ability to inhibit the carcinogenic p53-mdm2 interaction. Design of second-generation nonpeptidic compounds requires the reduction of large peptide structures down to small molecules maintaining the proper spatial arrangement of key functional groups. Molecular modeling software exists that can predict and rank intermolecular interactions from the p53-mdm2 complex crystal structure. Such analyses can yield a… CONTINUE READING

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