• DOI:10.1371/journal.pone.0109559
Corpus ID: 15866444

QM/MM Molecular Dynamics Study of the Galactopyranose → Galactofuranose Reaction Catalysed by Trypanosoma cruzi UDP-Galactopyranose Mutase

@article{PierdominiciSottile2014QMMMMD,
  title={QM/MM Molecular Dynamics Study of the Galactopyranose → Galactofuranose Reaction Catalysed by Trypanosoma cruzi UDP-Galactopyranose Mutase},
  author={Gustavo Pierdominici-Sottile and Rodrigo Cossio P{\'e}rez and Johan F Galindo and J. Palma},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}

Gustavo Pierdominici-Sottile, Rodrigo Cossio Pérez, +1 author J. Palma

Published 2014

Medicine

PLoS ONE

The enzyme UDP-Galactopyranose Mutase (UGM) catalyses the conversion of galactopyranose into galactofuranose. It is known to be critical for the survival and proliferation of several pathogenic agents, both prokaryotic and eukaryotic. Among them is Trypanosoma cruzi, the parasite responsible for Chagas' disease. Since the enzyme is not present in mammals, it appears as a promising target for the design of drugs to treat this illness. A precise knowledge of the mechanism of the catalysed… CONTINUE READING

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