QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.


The histone variant macroH2A1 contains a carboxyl-terminal ∼30-kDa domain called a macro domain. MacroH2A1 is produced as one of two alternatively spliced forms, macroH2A1.1 and macroH2A1.2. While the macro domain of macroH2A1.1 can interact with NAD(+)-derived small molecules, such as poly(ADP-ribose), macroH2A1.2's macro domain cannot. Here, we show that… (More)
DOI: 10.1128/MCB.05244-11


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