QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.

@article{Novikov2011QKImediatedAS,
  title={QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.},
  author={Leonid Novikov and Jong Woo Park and Hongshan Chen and Hadassa Klerman and Abubakar S. Jalloh and Matthew J. Gamble},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 20},
  pages={4244-55}
}
The histone variant macroH2A1 contains a carboxyl-terminal ∼30-kDa domain called a macro domain. MacroH2A1 is produced as one of two alternatively spliced forms, macroH2A1.1 and macroH2A1.2. While the macro domain of macroH2A1.1 can interact with NAD(+)-derived small molecules, such as poly(ADP-ribose), macroH2A1.2's macro domain cannot. Here, we show that changes in the alternative splicing of macroH2A1 pre-mRNA, which lead to a decrease in macroH2A1.1 expression, occur in a variety of cancers… CONTINUE READING
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