QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis

@inproceedings{Ivankov2013QARIPAW,
  title={QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis},
  author={Dmitry N. Ivankov and Natalya S. Bogatyreva and Peter H{\"o}nigschmid and Bastian Dislich and Sebastian Hogl and Peer-Hendrik Kuhn and Dmitrij Frishman and Stefan F. Lichtenthaler},
  booktitle={Nucleic Acids Research},
  year={2013}
}
Regulated intramembrane proteolysis (RIP) is a critical mechanism for intercellular communication and regulates the function of membrane proteins through sequential proteolysis. RIP typically starts with ectodomain shedding of membrane proteins by extracellular membrane-bound proteases followed by intramembrane proteolysis of the resulting membrane-tethered fragment. However, for the majority of RIP proteases the corresponding substrates and thus, their functions, remain unknown. Proteome-wide… CONTINUE READING

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Global analysis of the mitochondrial Figure 3 . Example of QARIP use . Identification of novel BACE 1 substrates ( for details see the text )

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