Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262.

@article{Ariyoshi2011Q172HRO,
  title={Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262.},
  author={Noritaka Ariyoshi and Miyuki Ohara and Mayumi Kaneko and Sakino Afuso and Takuya Kumamoto and Hiroyoshi Nakamura and Itsuko Ishii and Tsutomu Ishikawa and Mitsukazu Kitada},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 11},
  pages={2045-8}
}
There are a number of reports indicating that CYP2B6*6 (c.516G>T and c.785A>G) is responsible for decreased clearance of efavirenz (EFV), although increased disposition of cyclophosphamide (CPA) in individuals with this polymorphism was observed. Thus, we hypothesized that the effects of the two single nucleotide polymorphisms (SNPs) of CYP2B6*6 on the metabolism of drugs might be considerably different between these two agents. To clarify this possibility, we expressed two major variants of… CONTINUE READING