Q fever: persistence of antigenic non-viable cell residues of Coxiella burnetii in the host--implications for post Q fever infection fatigue syndrome and other chronic sequelae.

@article{Marmion2009QFP,
  title={Q fever: persistence of antigenic non-viable cell residues of Coxiella burnetii in the host--implications for post Q fever infection fatigue syndrome and other chronic sequelae.},
  author={Barrie P. Marmion and Olga A Sukocheva and Peter A. Storm and Mark E. Lockhart and Mark Turra and T Kok and J. Marx Ayres and Helen Routledge and Stephen Graves},
  journal={QJM : monthly journal of the Association of Physicians},
  year={2009},
  volume={102 10},
  pages={673-84}
}
BACKGROUND Our previous studies of persistence of Coxiella burnetii in humans after an initial acute Q fever infection revealed raised, maintained antibody levels and low levels of coxiella genomic DNA at the age of 5 years from onset in Australian patients and at 12 years in patients in the 1989 Birmingham UK Q fever outbreak. Attempts to isolate the coxiella in standard cell culture and susceptible mice by serial passage of PCR positive PBMC and bone marrow were negative. AIM To retest PCR… CONTINUE READING

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