Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-catenin Downregulation and AMPK Activation

  title={Pyrvinium Treatment Confers Hepatic Metabolic Benefits via $\beta$-catenin Downregulation and AMPK Activation},
  author={Shiwei Zhou and Obinna N Obianom and Jiangsheng Huang and Dong Guo and Hong Yang and Qing Li and Yan Shu},
Genetic evidence has indicated that β-catenin plays a vital role in glucose and lipid metabolism. Here, we investigated whether pyrvinium, an anthelmintic agent previously reported as a down-regulator of cellular β-catenin levels, conferred any metabolic advantages in treatment of metabolic disorders. Glucose production and lipid accumulation were analyzed to assess metabolic response to pyrvinium in hepatocytes. The expression of key proteins and genes were assessed by immunoblotting and RT… 
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