Pyruvic decarboxylase inhibition in ketoaciduria


A patient with intermittent episodes of cerebellar ataxia has been described (Pediat. 43:1025, 1969). The child excreted large amounts of urinary pyruvic acid during an episode which was studied in detail. Fibrobalst tissue culture cells were assayed for pyruvic decarboxylase and found to contain a low concentration of this enzyme. further examination of… (More)
DOI: 10.1203/00006450-197108000-00104