Pyruvate utilization, phosphocholine and adenosine triphosphate (ATP) are markers of human breast tumor progression: a 31P- and 13C-nuclear magnetic resonance (NMR) spectroscopy study.

@article{Singer1995PyruvateUP,
  title={Pyruvate utilization, phosphocholine and adenosine triphosphate (ATP) are markers of human breast tumor progression: a 31P- and 13C-nuclear magnetic resonance (NMR) spectroscopy study.},
  author={Samuel Singer and Kailene P. Souza and William G. Thilly},
  journal={Cancer research},
  year={1995},
  volume={55 22},
  pages={5140-5}
}
We have used 31P- and 13C-nuclear magnetic resonance spectroscopy to measure key metabolite levels and fluxes through enzymes regulating phospholipid and mitochondrial metabolism in normal human mammary epithelial cells. We have compared these values to those found in a progression series of breast cancer cell lines of varying metastatic potential established from a single patient. We find a 16-19-fold increase in phosphocholine content in two primary breast cancer cell lines (21PT and 21NT… CONTINUE READING

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Lack of assembly of mitochondrial DNA - encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND 4 gene product

  • A. M. Kaye, R. Hallowes, S. Cox, M. Sluyser
  • EMBO J .
  • 1993

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