Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration.

@article{Caneba2012PyruvateUI,
  title={Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration.},
  author={Christine A Caneba and Nad{\'e}ge Bellance and Lifeng Yang and Lisa M Pabst and Deepak Nagrath},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={303 8},
  pages={E1036-52}
}
Anoikis resistance, or the ability for cells to live detached from the extracellular matrix, is a property of epithelial cancers. The "Warburg effect," or the preference of cancer cells for glycolysis for their energy production even in the presence of oxygen, has been shown to be evident in various tumors. Since a cancer cell's metastatic ability depends on microenvironmental conditions (nutrients, stromal cells, and vascularization) and is highly variable for different organs, their cellular… CONTINUE READING