Pyruvate shuttle in muscle cells: high-affinity pyruvate transport sites insensitive to trans-lactate efflux.

@article{Mengual2003PyruvateSI,
  title={Pyruvate shuttle in muscle cells: high-affinity pyruvate transport sites insensitive to trans-lactate efflux.},
  author={Raymond Mengual and K el Abida and N. Mouaffak and Michel Rieu and Mich{\`e}le Beaudry},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 6},
  pages={
          E1196-204
        }
}
The specificity of the transport mechanisms for pyruvate and lactate and their sensitivity to inhibitors were studied in L6 skeletal muscle cells. Trans- and cis-lactate effects on pyruvate transport kinetic parameters were examined. Pyruvate and lactate were transported by a multisite carrier system, i.e., by two families of sites, one with low affinity and high capacity (type I sites) and the other with high affinity and low capacity (type II). The multisite character of transport kinetics… Expand
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