Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells.


Pyruvate is located at a crucial crossroad of cellular metabolism between the aerobic and anaerobic pathways. Modulation of the fate of pyruvate, in one direction or another, can be important for adaptative response to hypoxia followed by reoxygenation. This could alter functioning of the antioxidant system and have protective effects against DNA damage… (More)


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