Pyruvate oxidase of Streptococcus pneumoniae contributes to pneumolysin release

  title={Pyruvate oxidase of Streptococcus pneumoniae contributes to pneumolysin release},
  author={Joseph C. Bryant and Ridge C. Dabbs and Katie L. Oswalt and Lindsey R. Brown and Jason W. Rosch and Keun Seok Seo and Janet R. Donaldson and Larry S McDaniel and Justin A. Thornton},
  booktitle={BMC Microbiology},
Streptococcus pneumoniae is one of the leading causes of community acquired pneumonia and acute otitis media. Certain aspects of S. pneumoniae’s virulence are dependent upon expression and release of the protein toxin pneumolysin (PLY) and upon the activity of the peroxide-producing enzyme, pyruvate oxidase (SpxB). We investigated the possible synergy of these two proteins and identified that release of PLY is enhanced by expression of SpxB prior to stationary phase growth. Mutants lacking the… CONTINUE READING
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  • O Le Polain de Waroux, S Flasche, D Prieto-Merino, WJ. Edmunds
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