Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours.

@article{Mazurek2007PyruvateKT,
  title={Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours.},
  author={Sybille Mazurek},
  journal={Ernst Schering Foundation symposium proceedings},
  year={2007},
  volume={4},
  pages={99-124}
}
  • Sybille Mazurek
  • Published 2007 in Ernst Schering Foundation symposium proceedings
Normal proliferating cells and tumour cells in particular express the pyruvate kinase isoenzyme type M2 (M2-PK, PKM2). The quaternary structure of M2-PK determines whether the glucose carbons are degraded to pyruvate and lactate with production of energy (tetrameric form) or channelled into synthetic processes, debranching from glycolytic intermediates such as nucleic acid, amino acid and phospholipid synthesis. The tetramer:dimer ratio of M2-PK is regulated by metabolic intermediates, such as… CONTINUE READING