Pyruvate kinase type M2: a crossroad in the tumor metabolome.

  title={Pyruvate kinase type M2: a crossroad in the tumor metabolome.},
  author={Sybille Mazurek and Helmut Grimm and C Bruce Boschek and Peter Vaupel and Erich Eigenbrodt},
  journal={The British journal of nutrition},
  volume={87 Suppl 1},
Cell proliferation is a process that consumes large amounts of energy. A reduction in the nutrient supply can lead to cell death by ATP depletion, if cell proliferation is not limited. A key sensor for this regulation is the glycolytic enzyme pyruvate kinase, which determines whether glucose carbons are channelled to synthetic processes or used for glycolytic energy production. In unicellular organisms pyruvate kinase is regulated by ATP, ADP and AMP, by ribose 5-P, the precursor of the nucleic… CONTINUE READING


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