Pyruvate kinase deficiency and malaria.

  title={Pyruvate kinase deficiency and malaria.},
  author={Kodjo Ayi and Gundula Min-oo and Lena Serghides and Maryanne E Crockett and Melanie Kirby-Allen and I. C. Quirt and Philippe Gros and Kevin C Kain},
  journal={The New England journal of medicine},
  volume={358 17},
Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and there is evidence of coevolution of the plasmodium parasite with its host. In humans, pyruvate kinase deficiency is the second most common erythrocyte enzyme disorder. Here, we show that pyruvate kinase deficiency provides protection against infection and replication of P. falciparum in human… CONTINUE READING
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