Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma

@inproceedings{Hu2015PyruvateKM,
  title={Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma},
  author={Wen Dong Hu and Shi-Xun Lu and M. X. Li and Chao Zhang and Li-li Liu and Jia Fu and Jie-tian Jin and Rong-zhen Luo and Chris Zhiyi Zhang and Jing-ping Yun},
  booktitle={Oncotarget},
  year={2015}
}
Pyruvate kinase M2 (PKM2) contributes to the Warburg effect, a hallmark of cancer. We showed that PKM2 levels were correlated with overall survival (hazard ration = 1.675, 95% confidence interval: 1.389-2.019, P < 0.001) and disease-free survival (hazard ration = 1.573, 95% confidence interval: 1.214-2.038, P < 0.001) in a cohort of 490 patients with HCC. The correlations were further validated in an independent cohort of 148 HCC patients. Multivariate analyses revealed that PKM2 was an… CONTINUE READING

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