Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.

@article{Kefas2010PyruvateKM,
  title={Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.},
  author={Benjamin Kefas and Laurey D Comeau and Nicholas J Erdle and E M Montgomery and Samson Amos and Benjamin Purow},
  journal={Neuro-oncology},
  year={2010},
  volume={12 11},
  pages={
          1102-12
        }
}
  • Benjamin Kefas, Laurey D Comeau, +3 authors Benjamin Purow
  • Published in Neuro-oncology 2010
  • Medicine, Biology
  • Emerging studies have identified microRNAs (miRNAs) as possible therapeutic tools for the treatment of glioma, the most aggressive brain tumor. Their important targets in this tumor are not well understood. We recently found that the Notch pathway is a target of miRNA-326. Ectopic expression of miRNA-326 in glioma and glioma stem cells induced their apoptosis and reduced their metabolic activity. Computational target gene prediction revealed pyruvate kinase type M2 (PKM2) as another target of… CONTINUE READING

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