Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.

@article{Dong2015PyruvateKM,
  title={Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.},
  author={Tianfu Dong and Youde Yan and Hao Chai and Shenglin Chen and Xinkui Xiong and Daoyi Sun and Yue Yu and Lei Deng and Feng Cheng},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2015},
  volume={69},
  pages={
          277-84
        }
}
Cancer cells consume large amounts of glucose to produce lactate, even in the presence of ample oxygen. This phenomenon is known as the Warburg effect. The pyruvate kinase promotes aerobic glycolysis, and the pyruvate kinase M2 isoform (PKM2) is highly expressed in many cancer cells. Although the Warburg effect is a hallmark of cancer, the mechanism by which PKM2 contributes to the Warburg effect, and its role in tumor growth remain to be defined. We proposed that PKM2 activates transcription… CONTINUE READING
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