Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition.

Abstract

Recent studies have highlighted the fact that cancer cells have an altered metabolic phenotype, and this metabolic reprogramming is required to drive the biosynthesis pathways necessary for rapid replication and proliferation. Specifically, the importance of citric acid cycle-generated intermediates in the regulation of cancer cell proliferation has been… (More)
DOI: 10.1042/BJ20120294

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@article{Diers2012PyruvateFM, title={Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition.}, author={Anne R. Diers and Katarzyna A. Broniowska and Ching-fang Chang and Neil Hogg}, journal={The Biochemical journal}, year={2012}, volume={444 3}, pages={561-71} }