Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium.

@article{Knott2005PyruvatefortifiedCS,
  title={Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium.},
  author={E. M. Knott and M. Ryou and Jie Sun and Abraham Heymann and A. B. Sharma and Y. Lei and Mirza Baig and R. Mallet and A. Olivencia-Yurvati},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 3},
  pages={
          H1123-30
        }
}
Cardioplegic arrest for bypass surgery imposes global ischemia on the myocardium, which generates oxyradicals and depletes myocardial high-energy phosphates. The glycolytic metabolite pyruvate, but not its reduced congener lactate, increases phosphorylation potential and detoxifies oxyradicals in ischemic and postischemic myocardium. This study tested the hypothesis that pyruvate mitigates oxidative stress and preserves the energy state in cardioplegically arrested myocardium. In situ swine… Expand
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