Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension

@article{Sutendra2011PyruvateDI,
  title={Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension},
  author={Gopinath Sutendra and Peter Dromparis and S{\'e}bastien Bonnet and Alois Haromy and Michael Sean McMurtry and Robert Chris Bleackley and Evangelos D Michelakis},
  journal={Journal of Molecular Medicine},
  year={2011},
  volume={89},
  pages={771-783}
}
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced proliferation and suppressed apoptosis of pulmonary artery smooth muscle cells (PASMC). This apoptosis resistance is characterized by PASMC mitochondrial hyperpolarization [in part, due to decreased pyruvate dehydrogenase (PDH) activity], decreased mitochondrial reactive oxygen species (mROS), downregulation of Kv1.5, increased [Ca++]i, and activation of the transcription factor nuclear factor of… CONTINUE READING