Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation

  title={Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation},
  author={Henry Oppermann and Lutz Schnabel and J{\"u}rgen Meixensberger and Frank Gaunitz},
  pages={85848 - 85860}
Here we analyzed whether the anti-neoplastic effect of carnosine, which inhibits glycolytic ATP production, can be antagonized by ATP production via oxidative phosphorylation fueled by pyruvate. Therefore, glioblastoma cells were cultivated in medium supplemented with glucose, galactose or pyruvate and in the presence or absence of carnosine. CPI-613 was employed to inhibit the entry of pyruvate into the tricarboxylic acid cycle and 2,4-dinitrophenol to inhibit oxidative phosphorylation. Energy… 

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