Pyruvate Protects the Brain Against Ischemia–Reperfusion Injury by Activating the Erythropoietin Signaling Pathway

@article{Ryou2012PyruvatePT,
  title={Pyruvate Protects the Brain Against Ischemia–Reperfusion Injury by Activating the Erythropoietin Signaling Pathway},
  author={M. Ryou and R. Liu and Ming Ren and J. Sun and R. Mallet and Shao-Hua Yang},
  journal={Stroke},
  year={2012},
  volume={43},
  pages={1101–1107}
}
Background and Purpose— Pyruvate is known to be cytoprotective through antioxidant and anti-inflammatory mechanisms. We tested the hypothesis that pyruvate protects the brain against ischemia–reperfusion injury by inducing endogenous erythropoietin (EPO) expression. Methods— Pyruvate's protective effect was evaluated in C6 glioma cells and HT22 neuronal cells subjected to transient oxygen glucose deprivation. Cell viability (calcein AM assay) and expression of hypoxia-inducible factor-1&agr… Expand
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References

SHOWING 1-10 OF 36 REFERENCES
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
  • A. Sirén, M. Fratelli, +12 authors P. Ghezzi
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
  • 986
  • PDF
Estradiol Attenuates Programmed Cell Death after Stroke-Like Injury
  • 137
  • PDF
Protection by Pyruvate against Transient Forebrain Ischemia in Rats
  • 153
  • PDF
Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.
  • 18
  • PDF
Brain Genomic Response following Hypoxia and Re-oxygenation in the Neonatal Rat
  • 287
  • PDF
...
1
2
3
4
...