Pyruvate:ferredoxin oxidoreductase (PFO) is a surface-associated cell-binding protein in Trichomonas vaginalis and is involved in trichomonal adherence to host cells.

@article{MezaCervantez2011PyruvateferredoxinO,
  title={Pyruvate:ferredoxin oxidoreductase (PFO) is a surface-associated cell-binding protein in Trichomonas vaginalis and is involved in trichomonal adherence to host cells.},
  author={Patricia Meza-Cervantez and Arturo Gonz{\'a}lez-Robles and Rosa Elena C{\'a}rdenas-Guerra and Jaime Ortega-L{\'o}pez and Emma Saavedra and Erika Pineda and Rossana Arroyo},
  journal={Microbiology},
  year={2011},
  volume={157 Pt 12},
  pages={3469-82}
}
The Trichomonas vaginalis 120 kDa protein adhesin (AP120) is induced under iron-rich conditions and has sequence homology with pyruvate:ferredoxin oxidoreductase A (PFO A), a hydrogenosomal enzyme that is absent in humans. This homology raises the possibility that, like AP120, PFO might be localized to the parasite surface and participate in cytoadherence. Here, the cellular localization and function of PFO that was expressed under various iron concentrations was investigated using a polyclonal… CONTINUE READING

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