Pyrrylphenylethanones Related to Cathinone and Lefetamine: Synthesis and Pharmacological Activities

@article{Massa1992PyrrylphenylethanonesRT,
  title={Pyrrylphenylethanones Related to Cathinone and Lefetamine: Synthesis and Pharmacological Activities},
  author={S. Massa and R. D. Santo and A. Mai and M. Artico and Gian Carlo Pantaleoni and R. Giorgi and Maria Francesca Coppolino},
  journal={Archiv der Pharmazie},
  year={1992},
  volume={325}
}
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2‐chloro‐1‐(1‐methyl‐1H‐pyrrol‐2‐yl)‐2‐phenylethan‐1‐one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S. 
2 Citations

References

SHOWING 1-5 OF 5 REFERENCES
A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions.
  • 225
A note on a simple apparatus for detecting neurological deficit in rats and mice.
  • N. W. Dunham, T. Miya
  • Medicine
  • Journal of the American Pharmaceutical Association. American Pharmaceutical Association
  • 1957
  • 1,507
The pharmacology of khat.
  • P. Kalix
  • Chemistry, Medicine
  • General pharmacology
  • 1984
  • 149