Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246.

Abstract

Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity… (More)
DOI: 10.1016/j.bmcl.2008.10.032

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@article{Shiono2008PyrrospironesAA, title={Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246.}, author={Yoshihito Shiono and Keiko Shimanuki and Fuminori Hiramatsu and Takuya Koseki and Murayama Tetsuya and Nozomi Fujisawa and Ken-ichi Kimura}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 23}, pages={6050-3} }