Pyrrolysine Encoded by UAG in Archaea: Charging of a UAG-Decoding Specialized tRNA

@article{Srinivasan2002PyrrolysineEB,
  title={Pyrrolysine Encoded by UAG in Archaea: Charging of a UAG-Decoding Specialized tRNA},
  author={G. Srinivasan and C. James and J. Krzycki},
  journal={Science},
  year={2002},
  volume={296},
  pages={1459 - 1462}
}
Pyrrolysine is a lysine derivative encoded by the UAG codon in methylamine methyltransferase genes of Methanosarcina barkeri. Near a methyltransferase gene cluster is thepylT gene, which encodes an unusual transfer RNA (tRNA) with a CUA anticodon. The adjacent pylS gene encodes a class II aminoacyl-tRNA synthetase that charges the pylT-derived tRNA with lysine but is not closely related to known lysyl-tRNA synthetases. Homologs of pylS and pylT are found in a Gram-positive bacterium. Charging a… Expand

Paper Mentions

The direct genetic encoding of pyrrolysine.
  • J. Krzycki
  • Biology, Medicine
  • Current opinion in microbiology
  • 2005
Functional context, biosynthesis, and genetic encoding of pyrrolysine.
Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.
Misacylation of pyrrolysine tRNA in vitro and in vivo
tRNAPyl: Structure, function, and applications
Translation of UAG as Pyrrolysine
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