Pyrroloquinoline quinone protects nucleus pulposus cells from hydrogen peroxide-induced apoptosis by inhibiting the mitochondria-mediated pathway

@article{Yang2014PyrroloquinolineQP,
  title={Pyrroloquinoline quinone protects nucleus pulposus cells from hydrogen peroxide-induced apoptosis by inhibiting the mitochondria-mediated pathway},
  author={Lianjun Yang and Zijie Rong and Mingjun Zeng and Yanlin Cao and Xumeng Gong and Lijun Lin and Yong Chen and Wei Cao and Lixin Zhu and Weiren Dong},
  journal={European Spine Journal},
  year={2014},
  volume={24},
  pages={1702-1710}
}
Intervertebral disc cell apoptosis has been suggested to play a key role in promoting disc degeneration, and many studies have shown that the mechanism may be related to oxidative stress. Pyrroloquinoline quinone (PQQ), a redox cofactor for bacterial dehydrogenases, possesses the potential to scavenge reactive oxygen species (ROS) and inhibit cell apoptosis. The objective of this study was to evaluate the effects of PQQ on cultured rat nucleus pulposus (NP) cells under conditions of oxidative… CONTINUE READING
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ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

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Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.

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