Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice.

@article{Stites2006PyrroloquinolineQM,
  title={Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice.},
  author={Tracy Stites and David Storms and Kathryn A. Bauerly and James Mah and Calliandra Harris and Andrea J Fascetti and Quinton Rogers and Eskouhie H Tchaparian and Michael Satre and Robert B. Rucker},
  journal={The Journal of nutrition},
  year={2006},
  volume={136 2},
  pages={390-6}
}
When pyrroloquinoline quinone (PQQ) is added to an amino acid-based, but otherwise nutritionally complete basal diet, it improves growth-related variables in young mice. We examined PQQ and mitochondrial function based on observations that PQQ deficiency results in elevated plasma glucose concentrations in young mice, and PQQ addition stimulates mitochondrial complex 1 activity in vitro. PQQ-deficient weanling mice had a 20-30% reduction in the relative amount of mitochondria in liver; lower… CONTINUE READING

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