Pyrrolizidine alkaloids in food: a spectrum of potential health consequences

@article{Edgar2011PyrrolizidineAI,
  title={Pyrrolizidine alkaloids in food: a spectrum of potential health consequences},
  author={J. Edgar and S. Colegate and M. Boppr{\'e} and R. Molyneux},
  journal={Food Additives & Contaminants: Part A},
  year={2011},
  volume={28},
  pages={308 - 324}
}
Contamination of grain with 1,2-dehydropyrrolizidine ester alkaloids (dehydroPAs) and their N-oxides is responsible for large incidents of acute and subacute food poisoning, with high morbidity and mortality, in Africa and in central and south Asia. Herbal medicines and teas containing dehydroPAs have also caused fatalities in both developed and developing countries. There is now increasing recognition that some staple and widely consumed foods are sometimes contaminated by dehydroPAs and their… Expand
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  • 16
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5
...

References

SHOWING 1-10 OF 167 REFERENCES
Pyrrolizidine alkaloid toxicity in livestock: a paradigm for human poisoning?
  • 80
The toxic actions of pyrrolizidine (senecio) alkaloids.
  • E. McLean
  • Biology, Medicine
  • Pharmacological reviews
  • 1970
  • 375
Pyrrolizidine alkaloids in human diet.
  • 250
  • Highly Influential
Toxicology and carcinogenic action of pyrrolizidine alkaloids.
  • 148
  • PDF
Safety assessment of food and herbal products containing hepatotoxic pyrrolizidine alkaloids: interlaboratory consistency and the importance of N-oxide determination.
  • 34
LIVER DISEASE AND "NATURAL" HEPATOTOXINS.
  • R. Schoental
  • Biology, Medicine
  • Bulletin of the World Health Organization
  • 1963
  • 48
...
1
2
3
4
5
...