Pyrrolizidine alkaloids fromSymphytum officinale L. and their percutaneous absorption in rats

@article{Brauchli1982PyrrolizidineAF,
  title={Pyrrolizidine alkaloids fromSymphytum officinale L. and their percutaneous absorption in rats},
  author={J. Brauchli and Jacqueline Luethy and Ulla Li Zweifel and Ch. Schlatter},
  journal={Experientia},
  year={1982},
  volume={38},
  pages={1085-1087}
}
An analysis of a commercial sample of Symphyti radix originating from Poland with a total alkaloid content of 0.07% revealed the presence of 7 pyrrolizidine alkaloid-N-oxides: 7-acetyl intermedine, 7-acetyl lycopsamine as the main constituents and lycopsamine, intermedine, symphytine and traces of 2 further not yet identified alkaloids. The percutaneous absorption of these alkaloids was investigated in rats, using a crude alcoholic extract of the plant corresponding to a dose of 194 mg alkaloid… CONTINUE READING