Theoretical justification of a purposeful search of potential neurotropic drugs
- Chemistry, BiologyScienceRise: Pharmaceutical Science
Docking studies have identified a promising group of derivatives of 1-benzyl-4 (4-R-5sulfanylidene-4,5 dihydro-1H-1,2,4-triazol-3-yl) pyrrolidin-2-one, which have affinity for nootropic biotargets and are promising for further synthetic and pharmacological studies.
Progress on the Biological Activities of Helicid and its Derivatives
- Chemistry, BiologyCurrent Organic Chemistry
This compilation of 102 references may be helpful in understanding the diverse biological properties of helicid while providing insights into its mechanism of action and may direct future research in the synthesis of new derivatives and the exploration of other biological activities.
Effect of Piracetam , Vinpocetine and Ginkgo Biloba Extract on Antipsychotic-Induced Impairment of Learning and Memory
- Psychology, Medicine
Piracetam and vinpocetine, but not Ginkgo biloba extract, alleviate haloperidol-induced impairment of learning and memory in the MWM test.
Piracetam: a review of pharmacological properties and clinical uses.
- Medicine, PsychologyCNS drug reviews
Piracetam, a derivative of the neurotransmitter gamma-aminobutyric acid (GABA), has a variety of physiological effects that may result from the restoration of cell membrane fluidity, and its efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia.
Revisiting clinical practice in therapeutic drug monitoring of first-generation antiepileptic drugs
- Medicine, BiologyDrugs & Therapy Perspectives
This review summarizes the ongoing clinical practice utilizing TDM of first-generation or conventional AEDs, such as valproic acid, phenytoin, carbamazepine, phenobarbital, primidone, ethosuximide, clonazepam, clobazam, piracetam, and sulthiame.
Piracetam reverses haloperidol-induced catalepsy in mice
- Psychology, Medicine
It is indicated that the nootropic drug piracetam reduces haloperidol-induced catalepsy in mice, as well as vinpocetine, which was given as a 30-min pretreatment.
Monotherapy for partial epilepsy: focus on levetiracetam
- Medicine, PsychologyNeuropsychiatric disease and treatment
The combination of effective antiepileptic properties with a relatively mild adverse effect profile makes LEV an attractive therapy for partial seizures.
Studies on the synthesis and biological evaluation of the metabolite of clausenamide CM₂ and its stereoisomers.
- ChemistryEuropean journal of medicinal chemistry
Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update
- Medicine, PsychologyTherapeutic drug monitoring
An overview of the indications for AED TDM is provided, to provide key information for each individual AED in terms of the drug's prescribing indications, key pharmacokinetics characteristics, associated drug–drug pharmacokinetic interactions, and the value and the intricacies of TDM for each AED.
Effects of antiepileptic drugs on associative LTP‐like plasticity in human motor cortex
- Biology, PsychologyThe European journal of neuroscience
The particular depressant effect of levetiracetam on LTP‐like plasticity may also relate to the unique properties of this drug to inhibit epileptogenesis, a potentially LTP-associated process.