Pyrrolidinohydroquinazolines--a novel class of CCR3 modulators.

Abstract

A novel class of CCR3 modulators is described. Starting with lead compound 4a (K(i): 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (K(i): 28 nM), which surprisingly proved to be an agonist. 

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Cite this paper

@article{Anderskewitz2005Pyrrolidinohydroquinazolinesa, title={Pyrrolidinohydroquinazolines--a novel class of CCR3 modulators.}, author={Ralf Anderskewitz and Rolf Bauer and Gisela Bodenbach and Dirk Gester and Bernd Gramlich and Gerd Morschh{\"a}user and Franz W Birke}, journal={Bioorganic & medicinal chemistry letters}, year={2005}, volume={15 3}, pages={669-73} }