Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters.

@article{Zaafan2016PyrrolidinedithiocarbamateAB,
  title={Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters.},
  author={Mai A Zaafan and Hala F Zaki and Amany El-brairy and Sanaa Abdel Baky Kenawy},
  journal={Experimental lung research},
  year={2016},
  volume={42 8-10},
  pages={
          408-416
        }
}
OBJECTIVE The current study aimed to investigate the modulatory effects of pyrrolidinedithiocarbamate (PDTC; 100 mg/kg) on bleomycin-induced pulmonary fibrosis (5 mg/kg; intratracheal) in rats. MATERIALS AND METHODS Rats were randomly assigned to three groups: normal control, bleomycin control, and PDTC-treated groups. Lung injury was evaluated through histological examination, immunohistochemical detection of inducible nitric oxide synthase (iNOS) in lung tissue and evaluating the total and… CONTINUE READING

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