Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.

@article{Lauzurica1999PyrrolidineDP,
  title={Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha.},
  author={Pilaf Lauzurica and Sara Mart{\'i}nez-Mart{\'i}nez and M Ant{\'o}n Marazuela and P G{\'o}mez del Arco and Carlos Martinez and Francisco S{\'a}nchez-Madrid and Juan Miguel Redondo},
  journal={European journal of immunology},
  year={1999},
  volume={29 6},
  pages={1890-900}
}
Although important advances have been made in the development of antibiotics and medical intensive care technology in recent years, systemic response to infection remains a major health problem, with growing incidence and high mortality rates. Here we demonstrate the ability of the antioxidant agent pyrrolidine dithiocarbamate (PDTC) to inhibit the in vivo activation of NF-kappaB in lung and liver tissues, as well as the systemic release of TNF-alpha in lipopolysaccharide (LPS)-treated mice… CONTINUE READING
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