Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IkappaB kinase in embryonic hippocampal progenitor cells.

@article{Min2003PyrrolidineDN,
  title={Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IkappaB kinase in embryonic hippocampal progenitor cells.},
  author={Young Kyu Min and Jae Hyun Park and Seon Ah Chong and Yun Sook Kim and Young Soo Ahn and Jeong Taeg Seo and Young Suk Bae and Kwang Chul Chung},
  journal={Journal of neuroscience research},
  year={2003},
  volume={71 5},
  pages={689-700}
}
Pyrrolidine dithiocarbamate (PDTC) is known to induce cell death by the stimulation of intracellular zinc transport and subsequent modulation of nuclear factor-kappaB (NF-kappaB) activity. Zinc is a signaling messenger that is released by neuronal activity at many central excitatory synapses. Excessive synaptic release of zinc followed by entry into vulnerable neurons contributes to severe neuronal cell death. In the present study, we explored how PDTC modulates intracellular signal… CONTINUE READING

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